REFERENCES


Choose an author or browse all
Choose the species or browse all
Choose a criteria for sorting
 Reverse sorting
Search for a protein
Search for a single PMID
Download references as CSV

Select O-GlcNAc references filter

Click to expand (5 results)

*Color correspond to species


Zhang N, Meng Y, Mao S, Ni H, Huang C, Shen L, Fu K, Lv L, Yu C, Meekrathok P, Kuang C, Chen F, Zhang Y, Yuan K. FBXO31-mediated ubiquitination of OGT maintains O-GlcNAcylation homeostasis to restrain endometrial malignancy. Nature communications 2025 16(1) 39894887
Abstract:
Protein O-GlcNAcylation is a post-translational modification coupled to cellular metabolic plasticity. Aberrant O-GlcNAcylation has been observed in many cancers including endometrial cancer (EC), a common malignancy in women. However, clinical characterization of dysregulated O-GlcNAcylation homeostasis in EC and interrogating its molecular mechanism remain incomplete. Here we report that O-GlcNAcylation level is positively correlated with EC histologic grade in a Chinese cohort containing 219 tumors, validated in The Cancer Genome Atlas dataset. Increasing O-GlcNAcylation in patient-derived endometrial epithelial organoids promotes proliferation and stem-like cell properties, whereas decreasing O-GlcNAcylation limits the growth of endometrial cancer organoids. CRISPR screen and biochemical characterization reveal that tumor suppressor F-box only protein 31 (FBXO31) regulates O-GlcNAcylation homeostasis in EC by ubiquitinating the O-GlcNAc transferase OGT. Downregulation of O-GlcNAcylation impedes EC tumor formation in mouse models. Collectively, our study highlights O-GlcNAcylation as a useful stratification marker and a therapeutic vulnerability for the advanced, poorly differentiated EC cases.
O-GlcNAc proteins:
FR1L5, ERIC2, PKHG3, CCD78, ZN320, WDR27, MBPHL, CFA69, CDHR4, PINLY, VWA3A, NPB15, AKD1B, CC154, AGAP5, MET15, SAC31, CB081, TTL13, ENO4, CFA96, ZSWM8, OCAT2, NPIB5, LYRM9, ZBBX, CMI2B, NOTO, ARG33, CMA1B, DCD2C, IQCF6, ZN487, SHSA9, ADM5, PROB1, PTG3L, TM262, CK098, CS084, DCDC1, BACH, S28A1, SYT5, VMA5A, PITM1, MPP10, CCL22, EST2, P3C2B, UBE2C, TOR1A, P5I11, RPC1, PSA7, TR13B, RGS12, HAT1, CE290, NPFF, PGRC2, NPHP1, SIVA, TRI18, HMGB3, MRP3, INSI1, SRGP3, ADCY6, FGF16, IF4G3, ADA20, HTSF1, RAD21, NPA1P, L37A3, EREP2, NMD3B, TSN1, DPM1, TOM1, NSMA, HUS1, CTNS, AOC2, NPHP4, SNN, PROP1, PEX14, MED24, Z324A, UBP2, ZMY10, SPI2, IDHC, RBBP9, SOAT2, SPF27, DNJC8, FGF18, UBP1, BAIP3, FARP2, ZN432, KDM4B, HEXI1, UPP2, REC8, NDUB4, MRP6, RASL1, TACC2, RPGF3, BAG4, ATS2, ACSL3, RAB36, FRITZ, DRC4, CCNE2, ANF, PROC, PDGFA, LCAT, B3A2, CFAI, CO5A2, PGK2, RU2B, FGF4, PKHD1, SPRC, INHBB, F163B, OST4, PRR35, PAL4G, CGB3, VSIG8, COX8A, MYBB, RALA, CD79A, PCNA, ECP, PPA5, PRG2, OXDA, ZNF44, RFA2, UD2B7, STMN1, YBOX3, ZNF19, ZNF23, INAR1, SAP3, PRS6A, GBRB1, TNR1A, AOC1, AMY2B, PSB1, LMNB1, CAN3, CP3A5, HNF1A, CP2A7, ENDOU, ZNF10, DRD4, CCNO, CP7A1, CRYGS, EST1, RIR1, PAR1, MCM3, PSA2, PSA3, HMGB2, KAD4, PSB6, MZF1, RBL1, PTPRM, 3MG, PBLD, STX2, ERD22, MCM5, GALNS, SDC2, BMP8B, SPB6, RFA3, DEK, PRS7, GGT2, TNR3, TALDO, IF4A3, FEN1, HNF4A, M3K8, LAP2A, LAP2B, STAT6, MTHR, AL3B1, S15A1, MSS4, RFX2, INAR2, PRC2A, HSP13, GCST, PAXI, MAPK2, RPIA, CENPA, CENPF, PRI1, ACADV, NUMB, 5NTC, GUAA, DNLI4, ZNF83, IRAK1, CCR8, CLCN7, VAV2, ZN140, BIEA, MK10, OAZ1, AT1B3, DRG2, RAD, FGF8, UCN1, FOXA1, ALR, CTBP2, BCAR1, WDR4, CORO7, FBXW4, CABP4, RAB15, DJB13, SC61G, PTEN, SRP54, CKS1, PFD3, SUMO2, PP1A, PRS4, RUXG, LSM3, TYB4, TRA2B, 3BP2, RBM6, RPP38, HEPC, GPSM2, BAT1, RT35, CBX1, METK1, TF2B, CDK3, E2F1, MLRA, MYL5, ID2, P, HGFA, LGUL, RAD51, MCL1, PDE4C, SG11B, F27E3, DMPK, R51A2, INCA1, CF210, MGAT2, SFSWA, BIRC1, PAFA, IFT88, KLF10, SEM3B, PHLP, PPIG, PEX6, RB33A, DPOA2, SRC8, FLOT2, GALE, SLBP, HABP2, MCM6, TTLL4, RRP5, 2A5D, CND2, SPCS2, AR6P1, K0040, PEA15, CDK10, PON2, 2A5A, IRF4, TAF5, TAF1C, TRBP2, TRIP6, ZNF79, E2F4, ZN239, SNAT, NFE2, STX1A, MEA1, MK06, CDKN3, THTR, PCKGM, ZN827, MOONR, CL16A, MTHSD, FA83E, CF184, TECT1, PRSR3, TXIP1, CCD57, HKDC1, FHOD3, BTBDG, GFOD2, TKFC, TTLL9, DRC12, CDNF, HYDIN, SRCRM, PCDP1, CCD40, IQCC, PLCH1, VAS1L, PDCD4, LRC23, ZC21C, T4S20, FBLN7, CC157, M3K19, PAN3, TRI61, HERC4, MDH1B, ZN311, CC038, DYLT4, MEIG1, RRP12, WDR38, EFHC1, COL12, PA2GC, MANEA, PKHS1, SNPC4, F201A, F120S, MORN1, CFA70, UBX11, AXDN1, MRP7, ZFY27, AGRF1, CFA58, KIF24, SYT6, IER5L, ARM12, KAD9, DAAF9, CF163, RHG40, TMCO4, STPG1, EFCB6, CROCC, MEX3C, CBPC2, MCAF2, GP157, AXA81, CCD30, AGAP6, SLX4I, NXNL2, ARMC3, TTC23, FBX31, FBXW9, AL2CL, KFA, ATG9B, FTM, SLN13, FRPD2, Z518A, DMKN, TTLL5, ABLM2, ELP2, IQCE, CCSAP, ACD10, LCN12, OGFD2, NANP8, SAPL1, PWP2B, SWAP1, EFC12, NXRD1, ANR54, RM14, LTMD1, WDR93, EDC4, CP046, WDR73, PRS54, CP087, HAGHL, DCR1A, ATAD2, SPG17, ATRAP, ZN474, PLPR3, NHS, CC171, MAP12, GLB1L, BI2L2, RBP10, NSMF, CSC2A, DNMBP, DJC14, THADA, ZN497, LRC69, TMM91, DG2L6, PKHG7, MMS22, RHG27, FA47E, TM1L2, TTL10, KCP, UBP43, SMIM5, MED25, ZN765, CENPQ, MCM10, STRAA, MICA3, ZN367, APTX, TMC4, MUC19, DPOLN, SAXO4, CEA19, ADAT2, CATIP, ZN605, MYPN, YRDC, NHRF4, NLRX1, CAPS2, ST32C, THOC4, SESD1, WDR5B, TMM17, DAA11, NUD13, CNDG2, CTSR3, TXND6, DZIP3, PTH, TDRP, MYLK4, CASC2, RN135, CF337, ZN584, FMNL3, MSTN1, T151B, TRI59, CD302, CMA1C, DRC2, PGKA1, DRC7, CKP2L, DI3L2, SUV3, CCD13, SYTL1, REM2, CC170, KATL2, CFA46, RN168, DZI1L, AGRF2, CDK20, ASPM, TENS4, CENPL, ATOH7, F177A, ORML3, AHI1, CF107, ARG28, PYRD2, ABD12, LRC43, OR2LD, BBS5, PHTF2, TXND3, SVOPL, MINK1, ARL14, SPA6L, CCD24, LRC71, ARRD1, CC022, CCD33, TM148, CN178, BEND7, ADGB, CL076, ENDOV, S2529, CB069, IGS22, MUT7, CI163, SR1IP, ANR53, DAAF3, NLS1, NETO2, ZN485, MACA2, ADAD2, MORN4, CFA43, ZN248, TT21A, NSUN7, CS018, TTC16, DEN6B, ARMC2, DAAF1, TRPV1, WDR19, ANKK1, BHE22, BBS1, CC148, BEST4, NLGNY, CADM4, NEK11, OR1K1, O13C5, SVIP, DNJB8, CLHC1, GA2L2, ZSC18, PMFBP, ADA32, MIEAP, FANK1, SPP2B, SACA4, DLG5, NSUN6, TBCK, ZDHC1, NEUFC, S38A5, BLNK, OSCP1, SNR27, SKA2, TFB1M, STAG1, CQ050, TEKT4, DYDC1, SPIR2, S13A3, MB3L1, SREK1, MT21A, ASB13, ATS14, DYH7, PPM1E, TM234, CV015, TCPW, GBF1, LAR4B, NPIB3, PXDN, RSLAA, N42L2, DNSL2, OSTF1, HPS1, CLP1, WNT8B, SCAM4, TF3C6, LSM10, PMEPA, AKTS1, LENG9, ELMO3, ARL8A, ZN669, TIFA, EAF2, RB39B, DYH11, DRC10, RRFM, NGBR, OMA1, ZN837, CHFR, ADAT3, NEIL1, KIF12, IFT43, LRC46, HMCES, MED8, FAH2A, MSD3, CCD34, ZN845, RSRC1, TXD15, MRP9, MRP8, CHAP1, LRIQ1, BT3L4, DNJC1, RPGR1, ALPK3, IFT74, CCD17, CC74B, LRGUK, CFA53, KAD8, STAC3, HEXI2, PPM1M, CFA57, NOL4L, F218A, SPT33, CFA54, ZN396, SPT13, ODAD4, PCFT, AGAP4, FCRL4, ERMAP, ALS2, PRAM, ALPK1, 1A1L1, FCRL5, S26A8, MED15, IF140, CEP89, MBOA4, MMS19, INSM2, TBX5, TEAD3, CDCA3, SPSB2, RAD9A, ZN184, MGLL, ATX2, BARD1, FOXB1, SPAG8, RNZ2, TCF25, MEP50, LBHD1, PSD2, NEUL2, PIGQ, CPPED, HDHD3, GCP2, FEM1A, PHAF1, FUZZY, CHCH7, DERL1, DHRS6, RSRP1, KTNB1, KIFC3, DPCD, SMIM2, IFT27, THIC, NADAP, TM2D2, BBS2, TEKT3, IDI2, NUSAP, CAYP2, STK33, TRI55, BCDO2, DB126, FRMD8, PITM2, OSBL7, ULBP1, CHIA, B2L14, TSG10, SPEF2, ZFHX2, CFA74, ZN436, DYH6, LRC27, BSSP4, DNAI2, CHST5, CLPB, DRC9, ENKD1, TKTL2, MMP28, MIXL1, ZN106, VCX1, ABHGB, TOR3A, FA83D, COE3, MROH8, CSTP1, TM231, TASP1, CS044, CJ095, TBA4B, WDR76, CN093, COG4, MLXIP, KIF9, S28A3, SIAE, CLSPN, CYBP, NMUR1, IF122, PARVG, SPC25, LST2, ARGAL, NCK5L, LRC4C, SPCS, NRX3B, EMC7, UBE2T, SLAF7, TMM9B, TF7L2, IFT46, XPP3, ANM8, AAAS, STK36, SOSSC, GLRX2, CLTR2, KIF15, SEM4G, CT096, MITOS, KLH11, HAUS2, MED9, CB042, SIR5, MKS1, P4HTM, ARH38, PP4R2, BTG4, APC11, WSB2, MYOF, C1RL, CC167, KCMF1, RN181, SPAT7, CAC1I, DYH1, KIF17, C2D2A, MYEF2, ANKY1, SAE1, IF172, DPOLL, NAT8, RPGFL, NDUAC, SCNBA, DNAI1, TEKT2, PS1C1, KAD3, APC5, GGA1, DJC12, FBXL2, NXT1, RALY, TSN16, FBX5, INTU, TPC1, ABT1, AKP8L, GUC1B, PCDGG, PCDA6, RHG26, RBL2B, B9D1, ANR26, CE164, MOK, SPG7, LAMP3, COLQ, DLEC1, PSF2, KCNK6, INVS, ASF1A, FBW1A, VP9D1, SL9A8, WDR37, GSTK1, RT28, RPC10, UB2J1, COQ4, EXOS1, CBY1, DYR1B, AAKB1, NRX3A, C170B, SPEF1, IFT25, SHAN1, ASB4, CEP83, PCDGM, TM14A, CABIN, USH1C, TNR11, SCIN
Species: Homo sapiens
Download
Jin H, He H, Li J, Liu X, Cai Q, Shi J, Hao Z, He J. Mannose Inhibits NSCLC Growth and Inflammatory Microenvironment by Regulating Gut Microbiota and Targeting OGT/hnRNP R/JUN/IL-8 Axis. International journal of biological sciences 2025 21(4) 39990658
Abstract:
Recent studies have reported direct antitumor effects of mannose, a natural six-carbon monosaccharide, in the treatment of cancer. Herein, we utilized cancer cell lines, animal models, organoids and experimental techniques such as multi-omics and cellular experiments to investigate the regulatory effects of mannose on NSCLC growth and the inflammatory microenvironment. We demonstrated that mannose can inhibit cancer cell growth, inflammatory cell infiltration and inflammatory cytokine expression in NSCLC tissue, and enhance the antitumor efficacy of immune checkpoint inhibitor both in vitro and in vivo. Orally administered mannose increased the proportion of probiotics in the gut microbiota, the abundance of anti-inflammatory and antitumor metabolites in the blood and feces of NSCLC-bearing mice. In NSCLC cells, mannose reduced JUN mRNA stability and subsequent IL-8 transcription of NSCLC cells by directly targeting OGT to suppress the O-GlcNAc glycosylation of hnRNP R, which bound and stabilized JUN mRNA in an O-GlcNAc glycosylation dependent manner. Taken together, our study demonstrated that mannose can suppress NSCLC by inhibiting tumor growth and the inflammatory microenvironment, and serve as a promising adjunct medication.
O-GlcNAc proteins:
A0A0A0MR02, A0A0J9YXT7, A0A0S2Z471, A0A1B0GVI3, A0A1U9X8Y4, A0A1W2PNV4, A0A286YEZ8, A0A2R8Y5V9, A0A2R8Y6J3, A0A2R8YFE2, A0A384NYT8, A0A384P5S9, A0A3B3IUA8, A0A3S8NFS6, A0A5C2FYN0, A0A5C2G8J2, A0A6Q8PFJ0, A0A7I2V2S0, A0A7I2V323, A0A7I2V3I2, A0A7I2V4F0, A0A7I2V535, A0A7I2V599, A0A7I2YQB2, A0A7I2YQK5, A0A7P0TAE1, A0A7P0TAI0, A0A8I5KSD5, A0A8I5KWT8, A0A8I5KWU3, A0A8I5KY88, A0A8V8TNX9, A4QPB0, A8K3K1, A8K4T9, A8K4W0, A8K7F6, A8MUD9, B0QYK0, B2R7T8, B2R853, B2R9K8, B2RBD5, B2RBS8, B2RDE1, B2RE88, B3KRK4, B3KT06, B4DEB0, B4DF70, B4DIM6, B4DJI1, B4DMH3, B4DNX1, B4DTA2, B4DUQ1, B4DY08, B4E3P1, B5MDF5, B7Z2X4, B7Z2Z1, B7Z809, C9J614, D6RBZ0, D6REE5, E7ERF2, E9PCY7, E9PFP8, E9PKE3, E9PKZ0, E9PPH5, E9PQI8, F4ZW63, F5GY37, F8VRN8, F8W6I7, H0YJW3, H0YMD0, H3BQZ7, H3BRG4, H6VRF8, I6L9E8, J3QTR3, K7EL20, K7EPT8, K7ER77, K9MS24, M0QZM1, MYO1C, DDX3X, ARC1B, ARPC2, HNRPR, ACTN4, EDIL3, HNRPQ, CERU, ASSY, K1C14, ALDOA, G3P, HSPB1, RLA0, ENOA, PGK2, SYEP, HS90A, ASNS, VIME, K1C16, RSSA, POTEI, ADT3, ACTN1, XRCC5, EF2, K2C5, NUCL, FLNA, RS3, AT5F1, ATPA, RL13, EF1G, 1433T, EF1D, TRY3, K1C9, MYH10, K22E, ODO2, RBMX, RL3, AN32A, MAGA4, CAZA2, EFTU, TCPD, ROA3, HNRPF, CAZA1, RAB10, ARP3, ARP2, RS8, RS6, DCD, HNRPU, EF1A2, KHDR1, Q0QEN7, TWF1, ROA0, PSMD2, FLNC, AINX, DREB, FSCN1, H2A2C, H2B2E, Q1ZYL5, Q4VB24, Q53F48, Q53FI7, Q53G74, Q53G99, Q53HQ7, Q53ZX8, Q562L9, ACTBL, Q562Z4, Q59H77, Q5HYL6, Q5STU3, Q5TCU3, Q6B823, Q6GMV7, HORN, Q8IWP6, Q8TBR3, RBP56, Q96BS4, EFHD2, Q96IR1, TCPH, Q9BTI9, GAR1, Q9NZ23, CING, RTRAF, RTCB, SP16H, X6R700
Species: Homo sapiens
Download
Vang S, Helton ES, Guo Y, Burpee B, Rose E, Easter M, Bollenbecker S, Hirsch MJ, Matthews EL, Jones LI, Howze PH 4th, Rajasekaran V, Denson R, Cochran P, Attah IK, Olson H, Clair G, Melkani G, Krick S, Barnes JW. O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis. Frontiers in immunology 2024 15 38665916
Abstract:
Idiopathic pulmonary fibrosis (IPF) is a chronic pulmonary disease that is characterized by an excessive accumulation of extracellular matrix (ECM) proteins (e.g. collagens) in the parenchyma, which ultimately leads to respiratory failure and death. While current therapies exist to slow the progression, no therapies are available to resolve fibrosis.
O-GlcNAc proteins:
NUD4B, GAL3B, UBA6, HACL2, SPD2B, NBAS, SBNO1, VP37C, CNOT1, ZN316, DDTL, ZSWM8, P121C, GNAT3, EIFCL, C2D4D, IGLL5, NACAM, DNS2A, ADAS, PDLI1, BACH, MYO1C, AIP, GTPB1, AP3B1, PSD11, PSD12, PSMD9, ATOX1, CBX4, PGRC1, SPT5H, TAF4, DFFA, CLIC1, TR11B, EIF3F, ODPX, MATN2, QSOX1, WASL, IPO5, EMAL1, IF2B3, DNM1L, MANBA, PLOD2, MEIS1, PSDE, ZN593, IMA4, BCL9, PESC, NOP56, DDX3X, CCN1, IMA3, MA2B1, SCD, PLPP3, ARI1A, TRAD1, HSPB6, COPE, IF1AY, CCS, DVL2, TOR1A, P5I11, ANM5, NHRF1, TPP1, TCRG1, NRP1, PSA7, SCAM3, ML12B, HGS, MYPT1, GAK, HNRDL, XPO1, ZN609, SC16A, PLXB2, SR140, SET1A, SYNJ2, PUR4, NPC1, TBX3, ARC1B, ARPC2, ARPC3, TIF1A, NKRF, CASC3, RER1, SURF4, SPTC1, SPTC2, OGT1, PMM2, PPM1G, SHIP2, EIF3D, EIF3H, IPO8, STX7, MOT4, MRP4, P4HA2, NUP42, ARPC5, CLOCK, TPSN, KDM6A, DHX15, ASAP2, PRP4, SERA, DC1L2, PSMD3, RFOX2, PAPS1, SNUT1, DAPK3, TGFI1, CTIF, M3K7, MCA3, HNRPR, PRPF3, TXNL1, TPD54, EMC8, SYNJ1, IF4G3, ARK72, E41L2, B4GA1, FOXO3, RNF13, DENR, XPOT, PLRG1, ZN207, NDUA2, BUB3, ACTN4, AP1G1, SNG2, SGTA, SYNC, KRT86, MYO1B, CPSF5, LANC1, U3IP2, AKAP8, NRDC, CALU, EDIL3, SAHH2, EXTL3, MED14, SMCA5, TRAK2, GANP, FADS1, PEPL, NRP2, MA1A2, ACSL4, SNX3, OGA, HNRPQ, TPST1, NEMF, GREM1, PLOD3, SEP15, TSN3, PLIN3, MAFK, UGDH, CTND1, DPM1, USO1, RT14, H2B1K, PRAF2, DKC1, IF2P, DNJA2, BRD4, MITF, SRGP2, WDR1, ROCK2, CPNE3, PHF2, T22D2, PP6R2, CREST, ANR17, GGCT, NDUS2, ZPR1, DUS11, NIPS2, SEM7A, LX12B, TBCA, VATG1, H2AY, FLNB, NCOR1, NDUS6, CISY, SPAG7, SC22B, DEAF1, PR40A, MPPB, PSIP1, ERLN1, CLN5, CLD11, SF3B1, CSDE1, WBP4, PRKRA, LYPA1, ERAL1, U520, TIPRL, CRTAP, EIF3G, EIF3J, CBR3, FACE1, IDHC, ATRN, STAM2, PIAS1, PIAS2, DNJC8, SPF30, ATP5H, TRIO, CBPD, KT33A, KRT34, KRT36, RL1D1, WFS1, CLPX, STC2, PDE5A, SRP72, DDAH1, B3GA3, MTA2, AL1A2, TOM70, TOX4, SC24D, PHF14, CSCL1, TOX, SUN1, ERLN2, PRP6, NFAT5, GLSK, SC31A, CSTN1, YIF1A, AGFG2, SCAF4, ZFPL1, ELP1, NDUB8, LETM1, ZRAB2, LC7L3, VAPB, MPZL1, NDUAA, FKBP9, 6PGL, PAPS2, SMC2, IPO7, AGM1, SVIL, AHSA1, PSMG1, NSA2, G6PE, SC24A, SC24B, ETHE1, ACSL3, CNOT4, EYA4, K2C75, OXSR1, AP2A1, WIZ, STAU1, BAG2, BAG3, AIFM1, LATS1, BPNT1, FADS2, DDAH2, ABHGA, TXD12, FBLN4, RECK, NUDT3, NDUBA, CLPT1, TOM40, ACL6A, CYB5, LDHA, DHE3, NB5R3, GSHR, COX2, PNPH, HPRT, AATM, EGFR, PGK1, C1R, PLMN, UROK, TPA, ANT3, A2MG, CO3, CO5, TIMP1, CYTA, RASN, LDLR, TGFB1, IGHG1, IGHA1, HLAB, CO1A1, CO3A1, CRYAB, K1C14, K2C6A, LMNA, APOA1, APOC3, FIBA, FIBB, FINC, AMBP, FETUA, FETA, VTDB, TFR1, TRFE, TRFL, CATA, RAF1, GBA1, FUCO, ALDOA, ANXA1, APOB, GCR, PRIO, SODM, OAT, HRG, THY1, K2C6B, K2C1, G3P, HLAA, CPNS1, AMYP, HSPB1, RPN1, RPN2, GNAI2, AT1A1, A4, ARGI1, APOD, ALDH2, ITB3, S10A8, PAI1, ADT2, IF2A, RLA2, RLA0, JUN, LA, HEP2, ITB1, K1C18, K2C8, CO5A2, DCUP, LCK, GELS, PTMA, CDK1, ATPB, S10A9, S10A6, IF4E, ENOA, G6PI, NPM, ITAV, HEXA, H2B1J, GDN, HYEP, LDHB, PGK2, PDIA1, H10, CATD, ANXA2, CAN1, TBB5, TRY1, PGS2, SAP, HEXB, CATL1, PROF1, APT, SYEP, CATB, HS90A, HNRPC, LAMB1, TPM2, FUMH, TSP1, SP1, CO1A2, ANXA6, 4F2, PFKAM, HS90B, SRPRA, ASNS, ODPA, CY1, RU2B, RU17, ITA5, NFIC, VIME, A2AP, RS17, GNAI3, ANXA5, K1C16, STS, RSSA, CD63, FGF2, GSTP1, RU1C, LEG1, DHPR, HMGB1, SPRC, TPM1, CLCA, ANXA4, CN37, PGFRB, DLDH, ROA1, PARP1, UCHL1, LKHA4, ALDOC, CO4A, H2AZ, UCRIL, ATX1L, POTEI, ZN865, ZN888, INAM2, HS71A, GLI2, LYAG, HLAC, H14, ODP2, THIO, PPGB, MGST1, KAP0, ESTD, CH60, CLUS, BIP, LAMC1, PPAL, HSP7C, UMPS, ODPB, ODB2, PYGB, RALA, LAMP1, ACADM, FGFR1, TOP1, G6PD, PYC, C1TC, MPRI, ADHX, SRF, PABP1, PCNA, HARS1, CO6A1, CO6A2, CO6A3, ADT3, IMDH2, TPR, ACTN1, PEPD, XRCC6, XRCC5, COX41, IFM1, LAMP2, RINI, CSPG2, EF2, K1C13, K2C5, PDIA4, P4HA1, TCTP, HLAE, PLST, ACPH, ETFA, KAP2, ENOB, CD59, MIF, CD99, GLU2B, FPPS, NID1, AK1A1, KPYM, ENPL, RSMB, IDE, PO2F1, HNRPL, SYDC, PLAK, ALDR, AMPN, PVR, ERF3A, B4GT1, EZRI, ATF2, UCHL3, FOSL1, FOSL2, NDKA, GNS, ZEP1, ARSB, RS2, ITF2, TFE2, DESP, RFA2, CD44, CBR1, CREB1, PGFRA, BGAL, H15, H13, H12, NCPR, AT2A2, FAAA, STMN1, NAGAB, AATC, KPCA, JUNB, ITA2, ASM, UBF1, HXB6, ATF7, CAN2, DESM, CEBPB, PYRG1, EGLN, DDX5, LEG3, IBP3, TCPA, PTN1, IBP2, RL35A, ARF4, RL7, EGR1, VINC, SON, RL17, PGAM1, RCC1, ATF1, NUCL, HXK1, E2AK2, SPEE, CSK22, RXRA, ITIH2, ITIH1, NFKB1, FST, IF2B, ANXA7, CD22, RAB3B, RAB5A, PSB1, MPRD, COX5A, LMNB1, HXA5, IMDH1, CO5A1, FILA, GSTM3, VATB2, CSRP1, FLNA, ACOHC, 5NTD, VDAC1, PGS1, SDHB, COMT, TGM2, PIMT, FBRL, PUR2, PUR6, SCP2, UBA1, NDKB, SPR1B, SPR2E, ROA2, RFX1, CBL, IBP4, QCR2, TGM1, FBLN1, PGH1, ITA6, SFPQ, PPIB, MAOM, SYWC, RS3, SAHH, COF1, IF4B, AT2B4, DGKA, GATA2, CPT2, KTHY, RIR1, EF1B, IBP5, PPAC, THIL, TENA, MYL9, RPB1, PAR1, MCM3, NFYB, ZA2G, THTM, RS12, TYY1, DNJB1, DNJB2, ATPA, PSA1, PSA2, PSA3, PSA4, ITA3, MOES, DDX6, DNMT1, U2AF2, RL13, IVD, HMGB2, PTBP1, SYTC, SYVC, EF1G, FKBP2, STOM, 1433T, DPP4, ARNT, RL10, APEX1, PYR1, CALR, MAP4, CALX, PSB8, PSA5, PSB4, PSB6, PSB5, ABCD3, ITPI2, LYOX, ELK4, NDUS1, MK01, GRN, AMPL, TPP2, IMPA1, CCN2, EPHA2, EPHB2, TKT, SPB3, RBMS1, PML, EF1D, MARCS, GNA11, AL4A1, ERP29, PRDX6, BLVRB, PRDX5, PRDX3, ATPD, RL12, ECHM, PEBP1, PDIA3, 2AAA, CDC27, T4S1, NMT1, PURA2, UFO, AMRP, TSPO, PUR8, CLIP1, SORCN, CTR1, AL1B1, RPB2, LCN1, SDHA, GDIA, S10A7, METK2, RIR2, TIA1, ZEP2, DNJA1, AKT1, QCR1, 3HIDH, PUR9, HNRH3, HNRH1, CASPE, 1433B, STIP1, S10AB, PRDX2, P5CR1, GBP1, ELF1, RL9, KINH, DUT, MRP1, MCM4, MCM5, MCM7, CD68, GLYM, HSP74, PROF2, CTNA1, CTNB1, PHB1, RADI, RFA3, RFC2, RL22, CBS, K1C9, FBN1, FBN2, IRS1, MYH9, MYH10, COPB2, ADDA, BASI, TIMP3, FUS, NU214, DEK, SOX5, GLRX1, PRS7, MP2K2, ATPG, RL4, LONM, PGM1, PP1G, PEDF, ODO2, GPX4, SRP14, NUP62, TAGL2, TALDO, ETFB, RBMX, VKGC, VATA, HSPA9, IF4A3, RS19, RL3, COIA1, OST48, AN32A, FEN1, CAPG, IL6RB, TXLNA, TCPZ, NNMT, RL13A, STAT3, MDHC, MDHM, ECHA, IF2G, ETV6, WNT5A, BUD31, NAA10, CSK, GARS, SYIC, KPCI, LAP2A, LAP2B, MTREX, HUTH, CASP3, RS27, HELZ, LPPRC, THIM, RL35, PCP, ECE1, LIS1, MUC18, MATR3, SSRA, RANG, PRS6B, PPIC, VDAC2, CBX5, UBP5, RAGP1, RECQ1, NOP2, CRKL, BAG6, NSF, NOTC1, MP2K3, RL27A, RL5, RL21, RL28, RS9, RS5, RS10, MAP1B, YAP1, UTRN, IQGA1, STT3A, CAZA2, CAPZB, SYQ, RL29, LEG7, TISD, ATPO, LIMS1, PPCE, MAOX, RFX2, RFX5, SOX9, COPD, LSS, PP2BC, CD151, PRC2A, TCPE, NEST, HSP13, KC1D, IDHP, PIPNB, PAXI, NR2C2, AL9A1, RL34, LMAN1, NASP, FAS, CDK8, TCPG, EFTU, AL7A1, SRP09, PCY1A, SYAC, SYCC, SYSC, MA2A2, PSB2, MCM2, COMP, ACADV, YLPM1, TMEDA, RBM25, NUMB, HINT1, NU153, RBP2, GSK3A, TAF6, 5NTC, SEPP1, GUAA, IDH3A, MMP14, GDIB, EMD, CPT1A, SERPH, PDLI4, F10A1, VASP, DYN2, MAP2, TOB1, CDK9, BCAM, PPT1, RL14, TCPQ, TCPD, ANX11, PAPOA, RAB5C, RAB7A, RAB9A, DAP1, RT29, SMCA4, IDH3G, SSRD, BAP31, DHB4, PSMD7, SPHM, CLCN5, KS6A3, HDGF, LUM, CNN1, NDUA8, ROA3, 6PGD, HNRPM, IMA1, NCBP2, GDIR1, AGFG1, HNRPF, STAT2, TF2AA, MSH6, ZN143, RBM5, SPSY, THOP1, CAZA1, CRIP2, NUP98, BIEA, TXTP, PPP5, ACLY, FOSB, MAP11, SUCA, PGTB2, COPB, COPA, CATC, RPAB4, MOT1, SC24C, TCP4, SYRC, ATX1, ATN1, CA2D1, SYYC, UBP14, AAKG1, HSP72, BCAT1, AT1B3, RD23A, RD23B, ANAG, KAD2, P5CS, SNAA, IF5, PSMD4, DRG2, XPO2, TERA, ECHB, MANF, AF10, DSRAD, LAMB2, CAD11, CAD13, SEC13, NH2L1, PSA, HNRH2, SCOT1, EIF3B, BID, SYMC, ITA1, MAZ, ATP5E, ATP5I, HDAC4, IF6, CTBP2, BCAR1, TMM33, PCBP3, NU107, MTPN, ARPC4, TPIS, EIF3E, SC61B, PP4C, GBRL2, MYL6, ACTB, IF4A1, RS20, PRPS1, PSA6, S10AA, CDC42, DEST, SPCS3, SRP54, RAB2A, RAB10, UBC12, UBE2K, UBE2N, RAB14, ARP3, ARP2, ARF3, ABCE1, RAP1B, RS3A, RL26, RL15, MGN, RL27, VA0D1, RL37A, RHOA, CH10, S61A1, LYSC, STXB1, B2MG, DAD1, NPC2, COPZ1, SUMO2, UFM1, NTF2, HNRPK, 1433G, RS7, PP1A, PP1B, PRS4, PRS8, RS8, RS15A, RS16, 1433E, RS14, RS23, RS18, RS29, RS13, RS11, RUXE, RUXF, SMD1, SMD2, PRS10, RL7A, RB11A, ERF1, CNBP, YPEL5, RS4X, PP2AB, ACTA, RL23A, RS6, H4, RAB1A, RAN, RL23, RS15, RS25, RS26, RS28, RS30, GBB1, RBX1, GBB2, RL30, RL31, RL10A, RL32, RL11, RL8, PPIA, FKB1A, RS27A, GRB2, RAC1, AP2B1, VAMP2, GNAS2, 1433Z, SUMO1, RL38, SKP1, RS21, IF5A1, RACK1, ACTG, ACTH, PP2AA, YBOX1, SC11A, CSK2B, TPM4, UB2L3, EF1A1, TBA4A, TBB4B, CSK21, HBB, NOMO3, HBA, F193A, IGBP1, SHPS1, SERB, PITX1, IF4G2, GTF2I, CNTP1, PHC1, TCPB, RAE1L, GSTO1, PRKDC, MAP1A, NUCB2, DCD, SSBP2, SARNP, RL24, RL36A, SMAD3, ERH, RHOG, RL19, SRSF3, FOXK1, DAB2, FBLN2, PGBM, XIAP, RBM10, RBM3, CYC, S25A3, VIGLN, PURA, BORG5, CLH1, FKBP3, REEP5, DHSO, HNRPU, U2AF1, SPTB2, TIAR, SET, SRSF2, FOXK2, RUNX1, AMPD2, FABP5, CAP1, K22O, HMCS1, LAT1, EXOSX, OTUD4, PFKAP, EWS, PLCB3, ROR2, TAGL, MEF2A, ODO1, DSG1, SP3, RL18A, FKBP4, PLOD1, NUCB1, RL6, TOP2B, CREB5, AKA12, M2OM, DYST, CAV1, KMT2A, LMNB2, UPAR, TF65, GLGB, IF4G1, K1C17, NOTC2, TLE4, LGUL, AK1C1, 1433F, PLP2, CSTF1, UBE3A, FAK1, CALD1, COEA1, PUR1, GFPT1, SUH, MEF2C, GABPA, GABP1, PRDX1, RL18, CKAP4, ZO1, KHDR1, BAX, KLC1, ACK1, LRP1, SRSF1, RHG01, TLE5, TGM3, PP2BA, DHX9, QOR, GOGA3, GOGA2, LG3BP, DSC1, CD47, PPID, SSRP1, NSUN2, RBBP4, NCBP1, MGT5A, EP300, AHNK, IFFO1, INCA1, NEXN, MGAT2, GALT2, GALT1, AP1B1, CPSF1, MPPA, SCRN1, NU160, SCAP, SRBP2, TWF1, ASPH, FBLN3, TROP, BPTF, FSTL1, GRSF1, NFIA, SFSWA, SF3A3, SEPR, TP53B, AIMP1, ILF3, LMAN2, EPS8, TRAP1, TAF10, ECH1, STRN3, CDC16, FLII, CSN1, MTAP, AAPK1, EI2BE, TADBP, ROA0, AIMP2, PRDX4, PAK2, CBX3, PSMD2, TBX2, SRSF9, SRSF5, SRSF6, TIF1B, G3BP1, SG2A2, PTK7, PABP4, EIF3I, CTBP1, UB2V1, DC1I2, ILK, NNTM, TCOF, S39A6, SF3B2, ADAM9, TMED1, LSAMP, MYO9B, GAB1, SMAD4, PICAL, MAMD1, SQSTM, TBB3, ASAH1, PRP4K, PIN1, RIPK1, HDAC1, KCC2D, DCTN2, TRA2A, SNX1, CUL1, CUL4A, CUL4B, DYR1A, FCL, FHL1, FHL3, CD166, RUNX3, SPTN1, PKP1, DX39B, BLMH, TBB2A, IDI1, RUNX2, PEBB, NFYC, CDK13, CKAP5, COTL1, HNRPD, SCRB2, NID2, DAG1, VEZF1, EIF3A, UBP2L, SCRIB, GIT2, MLEC, TTL12, FHL2, DPYL3, DCTN1, DYHC1, SRC8, RCN2, TRI25, FLNC, FKBP8, FZD2, GAS6, CAPR1, RBM39, FAT1, SEM3A, MCM6, DSC3, PUM1, EPN4, SMC1A, RRP1B, NCOA6, GSE1, GANAB, 2A5D, LBR, MVP, LTBP1, LTBP2, MEF2D, CHD4, LASP1, ARI5B, PTGR1, NC2A, ZN638, IMB1, NOLC1, NUMA1, K2C72, CND2, PSMD6, SEPT2, SART3, CND1, U5S1, R3HD1, TRAM2, RB3GP, SYK, IF4H, BRD3, POSTN, OXA1L, EEA1, PDIA6, PA1B3, PCOC1, PLEC, IPYR, TEBP, NONO, RBBP5, RCN1, PCBP1, PCBP2, RHEB, DHC24, SF3B3, PUM3, DLGP5, RSU1, CNN3, SF3B4, SF3A2, RBMS2, SC23A, SF3A1, CDSN, SSXT, BGH3, NCOA2, TRAM1, SF01, MED1, JHD2C, TRIP6, MARE1, T22D1, ELAV1, ELF2, NAB2, MYLK, TAB1, AAAT, MLF2, ITSN1, TBCC, VAS1, ZFHX3, ZYX, ETFD, SEPT7, ADRM1, UAP1, IBP7, AINX, LAMA4, EXT1, PSMD5, CSRP2, DDB1, CDC37, DPYL2, KCC4, RBBP7, TAF9, ECM1, SRSF7, CPSF6, DREB, NRF1, FSCN1, IF16, DECR, GLO2, H2A2C, NDUA9, PCKGM, DDR2, HCDH, UGPA, TRXR1, MIC60, CPEB4, HNRL2, INF2, RFX7, QSER1, AAK1, PRSR3, QRIC1, LRRF1, P3H1, MA7D1, AL1L2, K2C71, TIM50, FUT11, TB10B, ANO6, FIL1L, SVEP1, AMOT, EPC2, FND3B, CRTC2, QORX, DHB12, CYBR1, IN80D, PAN3, YIF1B, F133B, ZN326, FILA2, MEST, HERC4, PIGG, BCORL, FA76B, TGO1, PREP, PRC2B, RRP12, TOIP1, PCID2, EOGT, TTC38, TM201, NU188, HP1B3, CE170, ZN362, FBP1L, FKB15, ZEP3, ZC3HD, LRIF1, UBR4, STXB5, RHG21, RM02, UBAP2, KPRP, KPLCE, RBM26, WLS, TUT4, H37, NT5D1, AHDC1, MRCKA, RPRD2, MYOME, ZN318, BROX, TASO2, PEAR1, MBNL2, ZMYM4, FHI2A, CD276, TSH3, TENS2, KANK2, AR6P4, OLM2A, HGNAT, ARID2, TENS3, CRBG3, RHG17, BICRL, AMERL, ATLA3, NXN, IQEC1, VASN, CPIN1, PTRD1, ELP2, LTOR1, TWF2, ADNP2, K2C80, LIN54, SCMC1, TM214, PPR18, CAVN1, CDC73, RM14, TATD1, EDC4, PRP8, SCYL2, GOLM2, NFRKB, RL22L, ALKB5, NCEH1, MDEAS, ZC3HE, OGFD3, LARP1, C1TM, FIP1, CRTC1, CSPG4, ARAID, LRSM1, TMCO3, LCLT1, CREL2, PAMR1, FAT4, MCAF1, CP2R1, PACS1, BCOR, MPRIP, HACD2, GGYF2, HSDL2, KAT3, CERS6, THSD4, MEX3B, ZN574, RN111, BAKOR, SRCAP, RIPR1, YJ005, TSH1, BGIN, UBN2, TMTC3, RAPH1, MOB2, IKIP, H32, LARP4, TBA1A, RS27L, HAKAI, ASXL2, CCD80, SPT6H, SND1, DDX46, 5MP2, DHX30, EIF3M, CYFP1, TAOK1, KDM3B, PHF5A, ERMP1, ZCCHV, NUP54, POGZ, MON2, K1C27, NUFP2, MAVS, CLAP1, DHX29, PLGT3, LIMS2, HDGR2, DCXR, EMSY, RAI1, I2BP2, RBBP6, SH3R1, RABEK, HUWE1, YTHD3, K2C1B, KHDC4, TMED4, COXM1, CENPV, GALT5, PHLB2, GLT10, MYPN, SYVN1, ACOT1, PABP2, LDB1, LYRIC, ZN598, KTN1, BCL9L, PHLB1, LUZP1, GP180, CAND1, HOOK3, TSYL5, CARM1, PRSR1, MEX3D, DDX42, P66A, HORN, RB6I2, RELL1, PLD3, FOXP4, P3H2, P3H3, CCD50, SPA12, CTL2, WDFY1, TEX2, NXP20, MGAP, Z3H7A, CHERP, ANKH1, SUGP1, CCAR1, DJC10, MSRB3, PLPL6, MILK2, SPB1, SMAP1, P20D2, PHAR4, ZNF34, ELMD2, DCP1B, XRN1, MAML2, ABI1, SELH, SPART, RPTOR, CCAR2, SIX5, NUP93, K2C78, ZCH24, LTBP4, ASCC3, SYNPO, FNBP4, AFAP1, CERS5, NKAP, CPSF7, ARFG2, ARFG1, LRC17, EMC1, ENAH, RM43, YP023, ANR52, GT251, SUMF2, SUMF1, PGLT1, PCYXL, TXND5, SCPDL, SERB1, LEMD2, NECP1, FA98A, CHSTE, APCDL, RN214, LS14A, TNR6A, PHC3, ABCF1, SP20H, ZNT7, NAV1, VP37A, FBX22, PCAT1, ZMIZ2, ARI1B, NUP35, NEUA, PLBL2, MFSD8, NEDD1, ZNT5, G45IP, SMRC2, NPL4, PUM2, KISHA, RDH11, STT3B, SPP2B, HM13, ALMS1, NEK9, PKHO2, DDX54, DLG5, NEK7, GPX8, GEMI5, IPO4, ZN384, SETD7, F222B, SMAP2, CHUR, CEMIP, PDC6I, FBLI1, PHLA1, NUDC2, SCFD1, POF1B, LMO7, ATX2L, SELM, PALLD, SREK1, PSPC1, P66B, AUTS2, ZCH14, IRGQ, DDB2, ASM3A, DDX1, S39A7, FAM3C, GBF1, SMG7, RTF1, NICA, TM9S4, TM131, RT27, F168A, PHF3, MAML1, HS105, LAR4B, GCN1, ZN516, NU205, PXDN, AN32B, NECT2, TFG, ARC1A, STAM1, REQU, SC65, CBP, GGH, NELL1, DDX17, TANK, CELF1, GSLG1, RENT1, CSN5, GATA6, SMRC1, FUBP2, TNPO1, ARHG2, UBP13, USP9X, UBP7, LPP, RBPMS, SMCE1, CAVN3, MYDGF, YIPF5, PIGT, RL36L, ZN622, WBP2, NCLN, MRTFA, ERGI1, RFT1, FERM2, FUBP1, TTC17, LRC59, PBIP1, FKB10, AKTS1, PF21A, EFHD2, GALM, INT12, CTHR1, KLH29, OPTN, AP2M1, RCN3, REPS1, KBP, DAZP1, RBM33, CK024, ZN503, I17RA, OTUB1, PGM2, CERS2, ZC21A, P121A, PDLI5, CREL1, ERO1A, PGAM5, FUBP3, SUCB2, GMPPA, KIRR1, WNK4, TMX3, CHAP1, ZFP91, PDLI2, ZC3HA, CLP1L, SCYL1, Z512B, CNDP2, ZFR, B3GT6, EP400, VATG3, PRRC1, ZN512, NOL4L, MBOA7, DOCK7, TOX2, SPB12, ARHGH, RBM14, QKI, LENG8, GSDMA, PP1RA, S38A2, VPS35, PHF12, SNX18, CIC, MED15, ERGI2, NUDC1, ERBIN, PIGS, WRIP1, RANB9, CLCC1, UBL7, MYADM, SIN3A, RUFY1, MINT, MMS19, UHRF1, NIBA2, HTF4, TBCB, NELL2, PSB7, CNN2, SEC62, PCY2, K1C12, CDC5L, PSMD1, SDF2, PARK7, EYA3, NEUR1, VAT1, LGMN, PLIN2, NUP88, MNT, SCAFB, DNJC7, PHB2, RGPD5, PITX2, ATX2, HCD2, COCA1, SMAD5, ROAA, LITAF, NP1L4, ACON, TM9S2, TS101, CPNE1, TCPH, EBP2, ANM1, SH3G1, CND3, DDX50, MEP50, VKOR1, TBA1C, SELS, MBB1A, COR1B, TXD17, VPS25, RM45, MXRA8, CAB45, ADPGK, PELO, ERP44, LXN, ESYT1, CNPY3, LIMD2, CSN4, WAC, DIDO1, DCTN5, AASD1, TMM43, TBCD, TBB6, HNRL1, HTAI2, DDX23, DHRS6, CA050, WDR18, THUM3, RN126, TBB2B, TM109, TMED9, NUP58, ELOV1, THIC, REPI1, RBM4, SFXN3, SSBP3, NAA15, KLF16, SRRT, TGT, HDHD5, EIF2A, CADM1, MK67I, YTHD1, WNK3, NEUL, RM37, GTPB4, UACA, RAB34, TBL1R, UBL5, EDEM3, API5, K1C23, UNK, FTO, TB182, AMRA1, TTYH3, ADSSP, PITH1, SKI8, SLIRP, WWTR1, TWSG1, NAA50, MKRN2, PAIP1, LSG1, NAT10, XRN2, SP130, BRD8, DDX47, MAGT1, LMA2L, SIL1, I2BPL, NUCKS, EHD4, VPS16, SH3L3, EPC1, SLK, S38A1, PDCL3, RBGPR, ADNP, DPH5, HIPK2, FOXP1, CK068, BOLA2, TMX1, NELFA, GCP60, PTN23, UN45A, OFUT1, WNK1, AMPB, GAPR1, ZHX3, EHD1, ZN768, SG196, CC134, PEAK1, AAMDC, WDR26, PKHG2, ZN703, ACAD9, GORS2, JUPI2, SYP2L, SFXN1, FKRP, ELP3, KT3K, FBRS, MLXIP, PKHA5, GBB4, XPO5, GRPE1, MYG1, RC3H2, TENS1, TAF9B, EMAL4, GLOD4, ZBT20, NCOA5, TANC2, MOV10, ZN532, ZN160, TNR6C, CHD8, SDF2L, CD248, SEC12, S10AE, AT131, RM47, CHM1A, TM9S3, APMAP, TRXR2, ARFG3, RAB18, VTA1, CD320, UBN1, DCP1A, TF7L2, RTN4, NIT2, NECT3, EXOS3, ANLN, XPP1, GEPH, PDLI7, DDX21, SAR1A, SIAS, SHLB2, MBNL1, 4ET, AAAS, STRN4, UBQL4, HEBP1, ABC3C, PHP14, F1142, TM7S3, KRT84, SYFB, SYIM, BMP2K, ATG3, SMC4, SAC1, OLA1, ZF64B, RBM12, ABHDA, SHFL, T106B, SPS2L, DD19A, TBC23, CC50A, SEP11, MED17, DJC11, INT7, ATD3A, ARL8B, DDX18, RT18A, NLE1, ZN358, RBM22, ARGL1, RM22, CZIB, GEMI8, F120C, OCAD1, IMPA3, MIC19, CKLF6, P4HTM, TOR4A, TRM1, CARF, DPP3, DDX56, BCLF1, TAB2, M3K20, UGGG2, UGGG1, CDK12, TECR, ERAP1, GGA3, F120A, GDE1, IF2B1, MAT2B, MYOF, ITSN2, BICRA, EHD2, CNOT2, CALL5, CRIM1, HACD3, KCMF1, RAI14, RM27, SENP1, SH3B4, PHRF1, RCC2, SLAI2, TEN3, CT2NL, RRBP1, SYLC, RBM27, KANL3, ANFY1, RERE, SUCB1, LRIT1, DPM3, SAE1, COPG2, MRC2, GBG12, DHCR7, DKK3, VPS29, EIF3K, GRHPR, CATZ, SAE2, NXF1, B4GT7, PEF1, FBLN5, CLIP2, ZO2, DNJB4, ADDG, ABCF2, TES, LIMD1, Z3H7B, TCF20, SUN2, LIMA1, SRP68, CHRD1, SEPT9, UBQL2, PCYOX, DDX20, ATS1, DPP2, CEIP2, NB5R1, S30BP, MED13, PUF60, NRBP, VATH, CBPA4, XPO7, BAZ2B, SIX4, GGT7, MSRA, NAGK, DBNL, DCTN4, CDC23, STML2, DBR1, AKA11, GMEB2, CPSF3, PARP4, RALY, ITA11, NUP50, ZHX1, ZN346, DNPEP, MCTS1, S39AA, ASAP1, MRTFB, HEG1, ZMIZ1, PRR12, YETS2, HECD1, ZMYD8, COR1C, NOTC3, SPAT2, PPT2, PRP19, UBQL1, SNX12, SYNRG, G3BP2, CHIP, PACN2, MAGD2, SNX6, PSD13, FAF1, PPIE, CSN3, MINP1, S12A4, MACF1, SCAF8, TRI33, TNR6B, SMAG1, CE164, FOXJ3, SHAN2, COR2B, SRRM2, PA2G4, ZN148, RTRAF, RUVB2, CLC11, EIF3L, PLAP, RUVB1, NUDC, VDAC3, COF2, ERGI3, SYFA, DRG1, NCKP1, PLAK2, ZN652, MA2B2, OFUT2, FND3A, E41L3, R3HD2, RRP44, LRCH1, GSTK1, DDX52, RT07, TMA7, MAN1, CHSP1, TR150, NOP58, ZN281, SGT1, ACOT9, NOSIP, MEMO1, SHLB1, LC7L2, SBDS, TMED7, ORN, UFC1, STRAP, RTCB, ZN330, RL36, SAMH1, TLN1, ARIP4, MTCL1, TCAF1, UBP15, LOXL2, CRBG1, HYOU1, TBL2, KLF12, ARI1, LSM4, RN114, PRC2C, RBM7, YTHD2, SP16H, SRPRB, MRCKB, ZN706, MAGD1, SNX5, HCFC2, FHOD1, SERC, NCOR2, NPTN, CBPQ, SOX21, RT18B, COPG1, FKBP7, GMEB1, CLIC4, EMIL1, MTCH2, 5MP1, DC1L1, EPN1, NEMO, IF2B2, ZNT1, NCOA3, NUMBL, PIAS3, ZHX2, S23IP
Species: Bos taurus, Homo sapiens
Download
Jiang K, Gao Y, Hou W, Tian F, Ying W, Li L, Bai B, Hou G, Wang PG, Zhang L. Proteomic analysis of O-GlcNAcylated proteins in invasive ductal breast carcinomas with and without lymph node metastasis. Amino acids 2016 48(2) 26374642
Abstract:
The potential role of protein O-GlcNAcylation in cancer has been studied extensively, and the spread of cancer cells to regional lymph nodes is the first step in the dissemination of breast cancer. However, the correlation between O-GlcNAcylation and lymphatic metastasis in breast cancer remains elusive. In this study, we demonstrated that the overall O-GlcNAcylation as well as O-GlcNAc transferase (OGT) tends to decrease in response to the augmentation of lymph node metastasis (LNM) in invasive ductal breast carcinomas (IDCs). Although accumulating evidence indicates that individual O-GlcNAcylation may be important in the pathogenesis of breast cancer, O-GlcNAcylated proteins in IDCs are still largely unexplored. Herein, O-GlcNAcylated proteins of IDCs were chemo-enzymatically enriched and identified via liquid chromatography combined with tandem mass spectrometry. In total, 155 O-GlcNAcylated proteins were determined, of which 41 were only observed in LNM tissues, while 40 were unique in non-LNM samples. Gene ontology analysis showed that O-GlcNAc is primarily a nucleocytoplasmic post-translational modification, and most enriched functional terms were related to cancer development in both metastatic and non-metastatic IDCs. Moreover, several O-GlcNAcylated proteins involved in glycolysis and its accessory pathway were identified from LNM and non-LNM groups, respectively. These results indicate that the O-GlcNAcylation statuses of individual proteins were independent of the overall O-GlcNAcylation levels of metastatic and non-metastatic IDCs. Aberrant O-GlcNAc modification of these proteins might be associated with LNM progression.
O-GlcNAc proteins:
IGLL5, NPT3, SURF4, OGT1, GGCT, LX12B, NCOR1, IDHC, AATM, ASSY, CYTA, PIGR, TRFL, CATA, VWF, G3P, HSPB1, ALDOB, ARGI1, ALDH2, S10A8, ATPB, S10A9, ENOA, PGK2, PDIA1, CATD, ANXA2, CAH3, GSTA2, GSTP1, F16P1, S31D3, UBC, THIO, CH60, HSP7C, LAMP1, ETFA, PLAK, DESP, HSP76, TGM1, LORI, ATPA, PSA5, PSB4, PSB6, GSTM2, TKT, SPB3, S10A7, CPSM, CASPE, S10AB, PRDX2, SPR1A, PGM1, TALDO, RL3, HUTH, SSRA, RS5, PSB2, CASP5, HMCS2, EPIPL, TPIS, IF4A1, RS3A, RS14, H4, RS24, 1433Z, ACTG, EF1A1, ACTS, HBB, ARF5, FABP5, DSG1, PRDX1, CKAP4, TGM3, DSC1, BLMH, DYHC1, DSC3, CDSN, SYPL1, HCDH, PTHD3, ACTBL, KPLCE, CNDH2, SBSN, DEN5B, FBX50, H32, H2AV, SPA24, HORN, KLD8B, POF1B, MUC16, TITIN, NAR4, BHMT1, MUCL1, DIRA2, SPB12, GSDMA, PSMD1, TCPH, PGES2, S10AE, ALG13, GNL3L, TBA8, ING1, NINL
Species: Homo sapiens
Download
Nandi A, Sprung R, Barma DK, Zhao Y, Kim SC, Falck JR, Zhao Y. Global identification of O-GlcNAc-modified proteins. Analytical chemistry 2006 78(2) 16408927
Abstract:
The O-linked N-acetylglucosamine (O-GlcNAc) modification of serine/threonine residues is an abundant posttranslational modification present in cytosolic and nuclear proteins. The functions and subproteome of O-GlcNAc modification remain largely undefined. Here we report the application of the tagging-via-substrate (TAS) approach for global identification of O-GlcNAc-modified proteins. The TAS method utilizes an O-GlcNAc azide analogue for metabolic labeling of O-GlcNAc-modified proteins, which can be chemoselectively conjugated for detection and enrichment of the proteins for proteomics studies. Our study led to the identification of 199 putative O-GlcNAc-modified proteins from HeLa cells, among which 23 were confirmed using reciprocal immunoprecipitation. Functional classification shows that proteins with diverse functions are modified by O-GlcNAc, implying that O-GlcNAc might be involved in the regulation of multiple cellular pathways.
O-GlcNAc proteins:
DFFA, PDXK, DHX15, SERA, ACTN4, SYNC, IF2P, IDHC, IPO7, ASSY, MYC, ALDOA, KITH, G3P, ENOA, G6PI, NPM, PGK2, ANXA2, PROF1, SYEP, HS90A, SP1, PFKAM, HS90B, PARP1, LKHA4, ALDOC, BIP, HSP7C, G6PD, C1TC, IMDH2, ACTN1, EF2, KPYM, EZRI, CBR1, LEG3, TCPA, PGAM1, NFKB1, ICAL, PRPS3, GSTM3, CSRP1, FLNA, PUR2, UBA1, SYWC, SAHH, COF1, RIR1, SYTC, SYVC, EF1G, PYR1, CALR, MAP4, 2AAA, CPSM, PUR9, PRDX2, CGL, MCM7, HSP74, CBS, MYH9, PRS7, RL4, PGM1, TAGL2, HSPA9, TCPZ, MDHC, MDHM, IF2G, GARS, SYIC, STA5A, LIS1, UBP5, IQGA1, CAPZB, COPD, PAXI, TCPG, EFTU, PSB2, HINT1, GDIB, TCPQ, TCPD, GPC3, ROA3, 6PGD, IMA1, GDIR1, MSH6, ACLY, COPB, COPA, CLH2, HSP72, KAD2, XPO2, EIF3B, ACTB, IF4A1, RL15, RS23, IF5A1, RACK1, ACTG, PP2AA, EF1A1, TBB4B, TCPB, VIGLN, CLH1, ODO1, IF4G1, PRDX1, KHDR1, TP53B, TRAF2, GNDS, GRIK2, MTAP, TADBP, PRDX4, PSMD2, DX39B, HNRPD, DYHC1, FLNC, MCM6, PLSI, MDC1, IMB1, NUMA1, PSMD6, PCBP2, ELOC, SF3B3, TERF2, MARE1, FSCN1, BROX, SND1, CAND1, PGAM4, ZN786, DDX1, GCN1, FUBP2, PSMD1, HCD2, ANM1, TBA1C, GPR87, IF5A2, SLK, DDX21, SYLC, HSPB8, PSME2, COR1C, PPME1
Species: Homo sapiens
Download
Page 1 of 1