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Kupferschmid M, Aquino-Gil MO, Shams-Eldin H, Schmidt J, Yamakawa N, Krzewinski F, Schwarz RT, Lefebvre T. Identification of O-GlcNAcylated proteins in Plasmodium falciparum. Malaria journal 2017 16(1) 29187233
Abstract:
Post-translational modifications (PTMs) constitute a huge group of chemical modifications increasing the complexity of the proteomes of living beings. PTMs have been discussed as potential anti-malarial drug targets due to their involvement in many cell processes. O-GlcNAcylation is a widespread PTM found in different organisms including Plasmodium falciparum. The aim of this study was to identify O-GlcNAcylated proteins of P. falciparum, to learn more about the modification process and to understand its eventual functions in the Apicomplexans.
O-GlcNAc proteins:
KC1, HSP70, ALF, TBA, PGK, CH60, EF1A, HXK, BIP, OAT, ENO, ACT1, ACT2, MYOA
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